Medical researchers have discovered a new kind of small-cell lung cancer (SCLC)

Medical researchers have discovered a new kind of small-cell lung cancer (SCLC). The discovery surely open the way for developing personalized medicine approaches to target this previously unnoticed form of the disease.

The research team, was led by Christopher Vakoc, M.D., Ph.D., a Cold Spring Harbor Laboratory (CSHL) Associate Professor, and found a paucity of neuroendocrine markers in pulmonary neuroendocrine cells, a cell type thought to be the source of SCLC.

"We were using the CRISPR screen to discover new vulnerabilities in this disease that we didn't know about before," Vakoc says. "The surprise is that in the process, we discovered a new form of lung cancer."

"In the past, we've lumped the different forms of SCLC together because they look similar on a microscope slide, but we now have some molecular tests that can easily discriminate these malignancies," says postdoctoral investigator Yu-Han Huang, first author on the new paper. "Our findings suggest that we should be designing clinical studies for them separately, to find therapies that might cater to the different types of tumor."

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