Posted by
Akinola Olusegun
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Posted by
Akinola Olusegun
on
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- Other Apps
Obesity is a major risk factor for diabetes mellitus and
cardiovascular disease. The societal cost of obesity is keeping pace
with the growing scope of the epidemic, estimated to account for ≈17% of
all US health expenditures by 2030.1
The clinical burden of obesity-related cardiovascular disease is
profound; recent data suggest that severe obesity (body mass index
>35 kg/m2) is associated with nearly a 4-fold increased
risk of incident heart failure and an ≈2-fold increased risk of incident
coronary heart disease and stroke.2
Given the strong associations between obesity and hypertension,
diabetes mellitus, and dyslipidemia, it is understandable that much of
the obesity-related coronary heart disease risk is attributable to
concurrent traditional risk factors such as hypertension, diabetes
mellitus, and dyslipidemia. However, data suggest a persistent risk
association between obesity and coronary heart disease that is not
explained by conventional risk factors, thereby spawning extensive
investigations to identify the culprit mechanisms.3
Over the past several decades, the research focus has shifted to the
adipose tissues themselves, and more specifically the adipocyte, as a
key link between obesity and cardiovascular disease risk.
Adipose tissue functions primarily as a storage depot for excess calories.FOR FULL ARTICLE CLICK HERE.
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