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Alzheimer’s disease reversed in mice, offering hope for humans

These promising research findings center around deleting a gene that produces an enzyme called BACE1, which helps make the beta-amyloid peptides that accumulate abnormally in the brains of people with Alzheimer’s disease. Studies have shown that stopping or reducing that enzyme’s activity dramatically reduces production of beta-amyloid peptides, which are toxic to the brain and lead to the symptoms — including memory loss — associated with Alzheimer’s. By using BACE1 inhibitors to gradually lower the enzyme’s levels, researchers saw reduced neuron loss and better brain function in the mice, offering hope for human subjects down the line, according to the study.

Ebola for kauri' spurs volunteers to alert Waitakare visitors to rahui

According to reports, local iwi placed the rahui restricting access to forest tracks in the 16,0000 hectare regional park to try to stop the spread of kauri dieback disease. "I think if people realised this was ebola for kauri they would realise that we need stricter protection measures," said Vivien Van Der Wal, one of the volunteers. Another volunteer Mataora Hoteke-Takirihi said: "People still will continue, knowingly or unknowingly, to go through. But that's okay. We're here to bring awareness as best we can."

New Imaging Technology May Help Predict Aggressiveness of Lung Cancer

Case Western Reserve and Cleveland Clinic are leading development of a computerized tissue-imaging program that could soon help identify which lung cancer patients are likely to face an earlier recurrence of the disease. With that information, cancer experts could more accurately determine which lung cancer patients should undergo aggressive post-surgery chemotherapy—and which are unlikely to benefit from it. “Right now, virtually all early-stage lung cancer patients get surgery,” said Anant Madabhushi, founding director of the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at the Case School of Engineering. “The problem is oncologists don’t currently have sufficient information to know which of these patients will also receive added benefit from chemotherapy.”

Pfizer and Merck KGaA suffered another setback with immuno-oncology med Bavencio

Pfizer and Merck KGaA have suffered another setback with immuno-oncology med Bavencio—and this one’s raising some eyebrows. Thursday, the companies revealed Bavencio (avelumab) had failed to outdo chemo at extending the lives of second-line lung cancer patients with PD-L1-positive tumors. And the way Evercore ISI analyst Umer Raffat sees it, there’s no “good reason” to explain the flop.

The U.S. Food and Drug Administration granted approval for expanded use of Imfinzi to treat non-small cell lung cancer (NSCLC) patients

The U.S. Food and Drug Administration said late on Friday it granted approval for expanded use of Imfinzi to treat non-small cell lung cancer (NSCLC) patients with inoperable mid-stage disease that has not spread widely around the body.
The green light - which had been expected following positive clinical data last year - gives AstraZeneca a chance to intervene earlier in lung cancer, distinguishing it from rivals that have approval for tackling advanced or metastatic disease. Analysts believe using Imfinzi in so-called stage III lung cancer, where cancer has only spread locally, opens up an annual sales opportunity worth around $2 billion. Importantly, AstraZeneca has a lead of two to three years over other drug companies in this particular area.

Symptoms of Low Blood Sugar : Feeling Dizzy or Shaky

Every diabetes patients should learn how to know whether their blood

sugar is low or high. In my two previous articles, i wrote about how

to know that your blood sugar is high through excessive

What counts as ultra-processed foods

What counts as ultra-processedMass-produced packaged breads and bunsSweet or savoury packaged snacks including crispsChocolate bars and sweetsSodas and sweetened drinksMeatballs, poultry and fish nuggetsInstant noodles and soupsFrozen or shelf-life ready mealsFoods made mostly or entirely from sugar, oils and fats